The 6-s RD protocol induced larger gains in MVIC at 30 o of knee angle measurement than the 2-s RD protocol. In addition, normalized EMG amplitude-angle and force-angle relationships were assessed in the 6 th and 39 th experimental sessions.

Rectus femoris and vastus lateralis cross-sectional areas (CSA), maximal voluntary isometric contraction (MVIC) at 30 o and 90 o of knee flexion and 1RM performance were assessed before and after the training period. Both protocols were performed with 3–4 sets, 50–60% of the one-repetition maximum (1RM), and 3 min rest. The left and right legs of ten untrained males were assigned to either one of the two protocols (2-s or 6-s RD) incorporating unilateral knee extension exercise. This study investigated the effects of two 14-week resistance training protocols with different repetition duration (RD) performed to muscle failure (MF) on gains in strength and muscle hypertrophy as well as on normalized electromyographic (EMG) amplitude and force-angle relationships. Resistance training with different repetition duration to failure: effect on hypertrophy, strength and muscle activation. Cite this article Lacerda LT, Marra-Lopes RO, Lanza MB, Diniz RCR, Lima FV, Martins-Costa HC, Pedrosa GF, Gustavo Pereira Andrade A, Kibele A, Chagas MH. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Licence This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed.

7 Institute for Sports and Sport Science, University of Kassel, Mönchebergstraße, Kassel, Germany DOI 10.7717/peerj.10909 Published Accepted Received Academic Editor Scotty Butcher Subject Areas Anatomy and Physiology, Global Health, Kinesiology Keywords Repetition duration, Muscle failure, Muscle cross-sectional area, Strength performance, Training volume, Time-under-tension, Electromyography Copyright © 2021 Lacerda et al.

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